Novel Microencapsulation Technology Enhances Magnesium Absorption and Reduces Side Effects

A recent double-blind, randomized, cross-over clinical study has shed new light on the effectiveness of various magnesium (Mg) supplements. The research focused on comparing the plasma Mg levels in volunteers after consuming different Mg sources, including a novel microencapsulated formulation called MAGSHAPE™ microcapsules (Mg-MS), alongside more conventional options such as Magnesium Oxide (MgO), Magnesium Citrate (Mg-C), and Magnesium bisglycinate (Mg-BG).

The study involved 40 healthy participants who were placed on a low-Mg diet for a week. Blood samples were collected before and at various intervals (1, 4, and 6 hours) after ingesting each Mg product. The results revealed significant differences in the bioavailability and absorption rates of the different Mg sources.

MAGSHAPE™ microcapsules demonstrated superior performance, showing a significant increase in blood plasma Mg levels at all tested time points. In contrast, MgO and Mg-C only showed significant increases at 1 and 4 hours post-intake, respectively. Surprisingly, Mg-BG failed to produce any significant increase in Mg levels throughout the study period.

One of the most noteworthy findings was the sustained increase in plasma Mg levels provided by the Mg-MS microencapsulation technology over the entire 6-hour duration of the study. When directly compared to non-microencapsulated MgO, Mg-MS exhibited significantly higher Mg bioavailability.

Additionally, the study reported that Mg-MS reduced common side effects associated with Mg supplementation, such as increased intestinal motility and sensations of gastric heaviness. This improved tolerability could be a game-changer for individuals who have previously struggled with Mg supplementation due to gastrointestinal discomfort.

Commentary by YourDailyFit columnist Alice Winters:

This groundbreaking study on MAGSHAPE™ microcapsules marks a significant advancement in the field of magnesium supplementation. As a nutrition expert, I find several aspects of this research particularly compelling and worthy of further discussion.

First and foremost, the superior bioavailability of the Mg-MS formulation is a crucial finding. Magnesium is notoriously difficult for the body to absorb, and many popular supplements, despite their claims, often fall short in delivering adequate amounts of this essential mineral to the bloodstream. The sustained increase in plasma Mg levels observed with Mg-MS over a 6-hour period is impressive and suggests that this technology could revolutionize how we approach magnesium supplementation.

The comparison with other common Mg sources provides valuable context. The poor performance of Mg bisglycinate, often touted as a highly bioavailable form, is surprising and challenges some prevailing beliefs in the supplement industry. This underscores the importance of rigorous clinical testing rather than relying on theoretical bioavailability based on chemical structure alone.

The reduced side effects reported with Mg-MS are equally significant. Gastrointestinal distress is a common barrier to consistent magnesium supplementation for many individuals. If Mg-MS can indeed provide improved Mg levels without the typical digestive discomfort, it could greatly enhance compliance and, consequently, the overall effectiveness of magnesium supplementation programs.

However, it’s important to note some limitations of this study. The sample size of 40 participants, while sufficient for preliminary findings, is relatively small. Larger-scale studies would be beneficial to confirm these results across a more diverse population. Additionally, the study duration was relatively short. Long-term studies would be valuable to assess the sustained effects of Mg-MS supplementation over weeks or months.

From a formulation perspective, the microencapsulation technology employed in Mg-MS is intriguing. It would be interesting to learn more about the encapsulation process and materials used, as these factors can significantly influence both bioavailability and tolerability. The potential applications of this technology to other minerals or nutrients could open up new avenues for supplement innovation.

Price point and scalability are also important considerations not addressed in this study. While Mg-MS shows promise, its viability as a widely adopted supplement will depend on whether it can be produced cost-effectively at scale.

In conclusion, the MAGSHAPE™ microcapsules represent a promising advancement in magnesium supplementation. The combination of improved bioavailability and reduced side effects addresses two of the most significant challenges in current Mg supplementation strategies. As the supplement industry continues to evolve, innovations like Mg-MS that are backed by solid clinical evidence will likely play a crucial role in shaping the future of nutritional support. However, as with all emerging technologies, further research and real-world data will be essential to fully understand the long-term benefits and any potential limitations of this novel formulation.