Research Reveals Mixed Results on Creatine’s Effectiveness for Women Athletes
The widespread use of creatine as a dietary supplement has garnered significant attention in the sports nutrition world. While its benefits have been well-documented in male populations, the effectiveness of creatine supplementation for active females remains a topic of ongoing research and debate. A recent comprehensive review aimed to evaluate the impact of creatine on exercise performance in physically active women and assess the quality of existing research in this area.
The study, which analyzed data from 27 studies spanning from the earliest available records to July 2024, included a diverse range of female participants, from recreational athletes to elite competitors. The creatine interventions varied widely, with supplementation periods ranging from five days to 12 weeks and employing different dosage strategies.
The researchers categorized performance outcomes into three main areas: strength/power, anaerobic capacity, and aerobic performance. The results were mixed, with only a fraction of studies showing significant improvements compared to placebo groups. Specifically, 3 out of 11 studies reported enhancements in strength and power, 4 out of 17 studies showed improvements in anaerobic performance, and just 1 out of 5 studies indicated benefits in aerobic capacity.
One of the key findings of this review was the substantial variability in study quality. The researchers utilized the Critical Appraisal Skills Program randomized controlled trials checklist, along with four additional criteria specific to methodological considerations for research involving active females. Notably, most studies failed to adequately address these female-specific physiological factors, potentially limiting the applicability of their findings.
The heterogeneity observed across studies in terms of participant characteristics, performance tests, and creatine supplementation protocols further complicates the interpretation of results. This diversity, coupled with the overall small evidence base, presents significant challenges in drawing definitive conclusions about the efficacy of creatine supplementation for active women.
In summary, while some studies did report performance benefits, the majority found no significant improvements compared to placebo. The review highlights the need for more robust, well-designed studies that specifically consider the unique physiological characteristics of female athletes to better understand the potential benefits of creatine supplementation in this population.
Commentary by SuppBase columnist Alice Winters:

This comprehensive review of creatine supplementation in active females brings to light several crucial points that warrant further discussion. As an expert in supplement and health product commentary, I find the results both intriguing and somewhat concerning.
First and foremost, the mixed results across different performance domains highlight the complexity of creatine’s effects on the female physiology. The fact that only a small fraction of studies showed significant improvements over placebo is a stark contrast to the well-established benefits observed in male populations. This discrepancy raises important questions about the potential gender-specific responses to creatine supplementation and underscores the need for more targeted research in this area.
The variability in study quality is particularly troubling. The failure of most studies to adequately address female-specific physiological considerations is a glaring oversight that potentially undermines the validity of their findings. Factors such as menstrual cycle phase, hormonal contraceptive use, and female-specific body composition changes can significantly impact athletic performance and supplement efficacy. Future research must prioritize these considerations to provide more accurate and applicable results for female athletes.
The heterogeneity in participant characteristics, ranging from recreational to elite athletes, while providing a broad perspective, also complicates the interpretation of results. Different athletic levels may respond differently to creatine supplementation, and lumping these diverse groups together may mask important nuances in supplement efficacy.
Moreover, the wide range of creatine interventions used across studies – from five days to 12 weeks, with varying dosage strategies – makes it challenging to establish optimal supplementation protocols for women. This lack of standardization not only hampers our ability to draw firm conclusions but also leaves female athletes and their coaches without clear guidance on how to effectively incorporate creatine into their nutrition plans.
From a market perspective, this review exposes a significant gap in our understanding of creatine’s effects on female athletes. With the growing popularity of women’s sports and increasing focus on female-specific sports nutrition, there’s a clear need for more targeted research and product development in this area. Supplement companies should take note of these findings and invest in female-specific studies to better serve this expanding market segment.
In conclusion, while this review provides valuable insights, it ultimately highlights the inadequacies in our current approach to studying creatine supplementation in women. As the sports nutrition industry continues to evolve, it’s crucial that we address these gaps with rigorous, female-focused research. Only then can we provide evidence-based recommendations for creatine use that truly benefit active women across all levels of athletic pursuit.